Urinary heat shock protein 72 as a biomarker of acute kidney injury in dogs

Yaron Bruchim, Yochai Avital, Michal Horowitz, Michal Mazaki-Tovi, Itamar Aroch, Gilad Segev*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Early recognition of acute kidney injury (AKI) is important, as therapy is potentially more efficacious if instituted early in the course of disease. Urinary heat shock protein-72 to urinary creatinine ratio (uHSP72/uCr) was assessed as a diagnostic and prognostic marker in AKI in dogs. Fifty-three dogs were enrolled in five groups: healthy controls (n = 11), urinary tract infection (n = 10), chronic kidney disease (CKD; n = 11), AKI (n = 13), and acute decompensating CKD (n = 8). Urinary heat shock protein-72 to urinary creatinine ratio was highest in the AKI group (P < 0.001 when compared to the control and urinary tract infection groups, individually; P > 0.05 compared to each of the other two groups). The area under the curve (AUC) for the receiver operator characteristic (ROC) analysis of uHSP72/uCr to predict AKI, compared to the control group, was 0.97. A cutoff value of 0.20 ng/mg corresponded to sensitivity and specificity of 100% and 82%, respectively. Urinary heat shock protein-72 to urinary creatinine ratio was significantly lower in dogs categorized as survivors vs. non-survivors of AKI; ROC AUC, 0.91 (95% confidence intervals, 0.74–1.0). Urinary heat shock protein-72 to urinary creatinine ratio is a potentially useful diagnostic and prognostic biomarker of AKI in dogs.

Original languageAmerican English
Pages (from-to)32-34
Number of pages3
JournalVeterinary Journal
Volume225
DOIs
StatePublished - Jul 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

  • Acute renal failure
  • Canine
  • Chronic kidney disease
  • Lower urinary tract infection
  • Survival

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