Urinary interleukin-6 is a potentially useful diagnostic and prognostic marker of acute kidney injury in dogs

Hilla Chen*, Yochai Avital, Michal Mazaki-Tovi, Itamar Aroch, Gilad Segev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Interleukin-6 (IL6) is a pro-inflammatory cytokine implicated in the pathophysiology of urinary tract diseases. The objective of this study was to evaluate the diagnostic and prognostic utilities of urinary IL6 (uIL6) in dogs with acute kidney injury (AKI) and other urinary tract diseases. Methods: Eighty client-owned dogs were included and divided into four groups: AKI, chronic kidney disease (CKD), urinary tract infection and healthy controls. Urine samples were analysed for uIL6 and normalised to urinary creatinine (uIL6/uCr). Results: Dogs in the AKI group had higher uIL6/uCr compared with the control and CKD groups (p < 0.001 and 0.012, respectively). Receiver operator characteristic (ROC) curve analysis of uIL6/uCr as a diagnostic marker for AKI had an area under the curve (AUC) of 0.91 (95% confidence interval [CI], 0.81–1.0) with 82% sensitivity and 90% specificity (cutoff point 4.5 pg/mg) when including the AKI and control groups. ROC analysis including AKI compared with all other groups had an AUC of 0.77 (95% CI, 0.67–0.87) for the diagnosis of AKI with sensitivity and specificity of 71% and 78%, respectively (cutoff point 10.4 pg/mg). The 30-day mortality of the AKI group was 34%, and there was no difference in uIL6/uCr between survivors and non-survivors of AKI. Conclusions: uIL6/uCr is a potentially sensitive and specific diagnostic marker for AKI in dogs.

Original languageAmerican English
Pages (from-to)no
JournalVeterinary Record
Issue number8
StatePublished - 1 Oct 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Veterinary Record published by John Wiley & Sons Ltd on behalf of British Veterinary Association.


  • chronic kidney disease
  • creatinine
  • cytokine
  • pyelonephritis
  • renal biomarker
  • urinary tract infection


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