Use of a monoclonal, anti Plasmodium berghei antibody, cross reacting with P. falciparum, for the detection of P. falciparum in in vitro infected blood

Avi Pass; Boaz Avidor; Jacob Golenser; Reuven Laskov; Dov Sulitzeanu

doi:10.1016/0165-2478(85)90046-X

Use of a monoclonal, anti Plasmodium berghei antibody, cross reacting with P. falciparum, for the detection of P. falciparum in in vitro infected blood

Avi Pass^*, Boaz Avidor, Jacob Golenser, Reuven Laskov, Dov Sulitzeanu

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This report describes an immunoradiometric assay for Plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mAb) raised against P. berghei. In this assay, binding of the mAb to intact P. berghei parasites coated on microtiter plates is inhibited by solubilized P. falciparum infected red blood cells. The use of P. berghei parasites in conjunction with monoclonal antibodies should facilitate the development of an inexpensive and reproducible test for the immunodiagnosis of malaria.

Original language	English
Pages (from-to)	31-34
Number of pages	4
Journal	Immunology Letters
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/0165-2478(85)90046-X
State	Published - 1985

Keywords

Plasmodium berghei
Plasmodium falciparum
immunodiagnosis
monoclonal antibody

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10.1016/0165-2478(85)90046-X

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title = "Use of a monoclonal, anti Plasmodium berghei antibody, cross reacting with P. falciparum, for the detection of P. falciparum in in vitro infected blood",

abstract = "This report describes an immunoradiometric assay for Plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mAb) raised against P. berghei. In this assay, binding of the mAb to intact P. berghei parasites coated on microtiter plates is inhibited by solubilized P. falciparum infected red blood cells. The use of P. berghei parasites in conjunction with monoclonal antibodies should facilitate the development of an inexpensive and reproducible test for the immunodiagnosis of malaria.",

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author = "Avi Pass and Boaz Avidor and Jacob Golenser and Reuven Laskov and Dov Sulitzeanu",

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T1 - Use of a monoclonal, anti Plasmodium berghei antibody, cross reacting with P. falciparum, for the detection of P. falciparum in in vitro infected blood

AU - Pass, Avi

AU - Avidor, Boaz

AU - Golenser, Jacob

AU - Laskov, Reuven

AU - Sulitzeanu, Dov

PY - 1985

Y1 - 1985

N2 - This report describes an immunoradiometric assay for Plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mAb) raised against P. berghei. In this assay, binding of the mAb to intact P. berghei parasites coated on microtiter plates is inhibited by solubilized P. falciparum infected red blood cells. The use of P. berghei parasites in conjunction with monoclonal antibodies should facilitate the development of an inexpensive and reproducible test for the immunodiagnosis of malaria.

AB - This report describes an immunoradiometric assay for Plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mAb) raised against P. berghei. In this assay, binding of the mAb to intact P. berghei parasites coated on microtiter plates is inhibited by solubilized P. falciparum infected red blood cells. The use of P. berghei parasites in conjunction with monoclonal antibodies should facilitate the development of an inexpensive and reproducible test for the immunodiagnosis of malaria.

KW - Plasmodium berghei

KW - Plasmodium falciparum

KW - immunodiagnosis

KW - monoclonal antibody

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JO - Immunology Letters

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IS - 1

ER -

Use of a monoclonal, anti Plasmodium berghei antibody, cross reacting with P. falciparum, for the detection of P. falciparum in in vitro infected blood

Abstract

Keywords

UN SDGs

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