Abstract
Objective: To determine which measure is the most sensitive to noise induced hearing loss (NIHL): auditory nerve brainstem response (ABR), distortion product otoacoustic emission (DPOAE) or transient evoked otoacoustic emission (TEOAE), and how to assess possible changes in these responses. Subjects & Methods: Four groups of rats were exposed to various durations of 113 dB SPL broadband noise: 5 or 10 minutes (temporary changes in cochlear function), and 3 or 4 hours (permanent changes). Group means and data from individual animals were compared before and after exposure. Results: Mean group DPOAE amplitude reduction showed no clear advantage over mean ABR threshold elevation in detection of temporary and permanent NIHL. Data from individual rats, however, indicated a clinical advantage for DPOAEs in detecting slight temporary, but not permanent, changes. TEOAEs were more sensitive in detecting changes in individual rats than as a group measure. Conclusions: TEOAE and DPOAE monitoring may improve detection of NIHL, though it should be used in conjunction with audiometric threshold monitoring.
Original language | English |
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Pages (from-to) | 95-118 |
Number of pages | 24 |
Journal | Journal of Basic and Clinical Physiology and Pharmacology |
Volume | 14 |
Issue number | 2 |
DOIs | |
State | Published - 2003 |
Keywords
- ABR
- DPOAE
- hearing loss
- noise
- PTS
- rat
- TEOAE
- TTS