TY - JOUR
T1 - Use of acute phase proteins for the clinical assessment and management of canine leishmaniosis
T2 - General recommendations
AU - Ceron, J. J.
AU - Pardo-Marin, L.
AU - Caldin, M.
AU - Furlanello, T.
AU - Solano-Gallego, L.
AU - Tecles, F.
AU - Bernal, L.
AU - Baneth, G.
AU - Martinez-Subiela, S.
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/6/20
Y1 - 2018/6/20
N2 - Background: Dogs with canine leishmaniosis (CanL) due to Leishmania infantum can show a wide spectrum of clinical and clinicopathological findings at the time of diagnosis. The aim of this paper is to describe the possible application of acute phase proteins (APPs) for the characterization and management of this disease, based on previously published information on the utility of APPs in CanL and the experience of the authors in using APPs as analytes in the profiling of canine diseases. Main body: Dogs diagnosed with L. infantum infection by serology, polymerase chain reaction, cytological or histopathological identification, can be divided into three groups based on their clinical condition at physical examination and their APPs concentrations: Group 1: dogs with no clinical signs on physical examination and APPs in reference range; Group 2: dogs with changes in APPs but no clinical signs on physical examination; Group 3: dogs with clinical signs and changes in APPs. This report describes the main characteristics of each group as well as its association with the clinical classification schemes of CanL. Conclusion: APPs concentration can be a useful clinical tool to characterize and manage CanL.
AB - Background: Dogs with canine leishmaniosis (CanL) due to Leishmania infantum can show a wide spectrum of clinical and clinicopathological findings at the time of diagnosis. The aim of this paper is to describe the possible application of acute phase proteins (APPs) for the characterization and management of this disease, based on previously published information on the utility of APPs in CanL and the experience of the authors in using APPs as analytes in the profiling of canine diseases. Main body: Dogs diagnosed with L. infantum infection by serology, polymerase chain reaction, cytological or histopathological identification, can be divided into three groups based on their clinical condition at physical examination and their APPs concentrations: Group 1: dogs with no clinical signs on physical examination and APPs in reference range; Group 2: dogs with changes in APPs but no clinical signs on physical examination; Group 3: dogs with clinical signs and changes in APPs. This report describes the main characteristics of each group as well as its association with the clinical classification schemes of CanL. Conclusion: APPs concentration can be a useful clinical tool to characterize and manage CanL.
KW - Acute phase proteins
KW - Canine leishmaniosis
KW - Staging
UR - http://www.scopus.com/inward/record.url?scp=85048872842&partnerID=8YFLogxK
U2 - 10.1186/s12917-018-1524-y
DO - 10.1186/s12917-018-1524-y
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C2 - 29925385
AN - SCOPUS:85048872842
SN - 1746-6148
VL - 14
JO - BMC Veterinary Research
JF - BMC Veterinary Research
IS - 1
M1 - 196
ER -