Use of fractal geometry to determine effects of surface morphology on drug dissolution

Dina Farin, David Avnir*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

We extend and modify the Noyes‐Whitney equation and the Hixon‐Crowell cube root law to include surface roughness effects on the dissolution rate of drugs. The problem is treated theoretically in terms of the fractal reaction dimension, DR, of the effective surface which undergoes dissolution. Effects of changes in DR on the dissolution rate are identified and explained.

Original languageEnglish
Pages (from-to)54-57
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume81
Issue number1
DOIs
StatePublished - Jan 1992

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