Abstract
We extend and modify the Noyes‐Whitney equation and the Hixon‐Crowell cube root law to include surface roughness effects on the dissolution rate of drugs. The problem is treated theoretically in terms of the fractal reaction dimension, DR, of the effective surface which undergoes dissolution. Effects of changes in DR on the dissolution rate are identified and explained.
Original language | English |
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Pages (from-to) | 54-57 |
Number of pages | 4 |
Journal | Journal of Pharmaceutical Sciences |
Volume | 81 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1992 |