Using PEGylated nano-liposomes to target tissue invaded by a foreign body

Avi Schroeder, Alex Sigal, Keren Turjeman, Yechezkel Barenholz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The ability of nano (∼100 nm) sterically stabilized liposomes (nSSLs) to target tissue invaded by a foreign body was demonstrated. Radioactively labeled nSSL remote loaded with the anti-inflammatory drug methylprednisolone hemisuccinate (MPS), to form nSSL-MPS, were injected i.v. to mice that, 2 or 3 weeks earlier, had either a thorn or a needle implanted in a hind leg. Twenty-four hours post-nSSL-MPS injection, animals were sacrificed, and the level of liposomes in the vicinity of the foreign body, in comparison to the tissue in the contralateral (normal) leg, was measured. The level of liposomes in the tissue surrounding the foreign body was twice as high as the level of liposomes found in the normal leg. Furthermore, the level of liposomes in the normal leg was similar to the level of liposomes measured in the legs of control animals that did not have an implanted foreign body and were treated with nSSL-MPS. The implications of these findings and the clinical applications of liposomal targeting are discussed.

Original languageAmerican English
Pages (from-to)591-595
Number of pages5
JournalJournal of Drug Targeting
Issue number7-8
StatePublished - 2008

Bibliographical note

Funding Information:
Avi Schroeder thanks the Barenholz Fund for its financial support; Mr Sigmund Geller is acknowledged with pleasure for his help in editing this manuscript.


  • Foreign body injury
  • Inflammation
  • Passive targeting
  • Shrapnel
  • Sterically stabilized liposome


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