Utility of 1,2-o-dilauryl-rac-glycero glutaric acid-(6′-methylresorufin)-ester-lipase for monitoring dogs with chronic pancreatitis

Sharon Kuzi*, Dana Adlersberg, Itamar Aroch, Gilad Segev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The utility of 1,2-o-dilauryl-rac-glycero glutaric acid-(6′-methylresorufin)-ester-(DGGR)-lipase activity (DLA) in monitoring clinical progression of chronic pancreatitis (CP) in dogs is unknown. Objective: To examine the association of DLA with clinical signs of CP, as assessed by a CP clinical severity score (CPCSS). Animals: Twenty-four dogs. Methods: This is a retrospective study. Chronic pancreatitis was diagnosed based on clinical signs and DLA > 250 U/L and monitored using CPCSS and DLA. Results: The study included 134 visits (median, 10 visits/dog; range, 2-11). Mild-moderate (CPCSS, 0-3) and severe (CPCSS, ≥4) disease were documented in 94 (70%) and 40 (30%) visits, respectively. In emergency visits (n = 44; 33%) CPCSS (median, 5; range, 0-15) and DLA (median, 534 U/L; range, 63-7133) were higher (P <.001 and P =.003, respectively) than in scheduled ones (n = 90; 67%; median, 1; range, 0-6 and median, 384 U/L; range, 49-3747, respectively). DGGR-lipase activity was associated (P =.009) with the CPCSS, with a lower activity documented in mild-moderate CPCSS (median 391 U/L; range, 49-3747), compared to severe score (median, 558 U/L; range, 63-7133). DGGR-lipase activity was significantly, but weakly, correlated with CPSS (r = 0.233, P =.007). DGGR-lipase activity inefficiently discriminated mild-moderate vs severe CP (area under the receiver operator characteristics curve, 0.64; 95% confidence interval, 0.53-0.75; P =.012), with DLA cutoff of 428 U/L corresponding to sensitivity of 65% and specificity of 63%. Conclusions and Clinical Importance: Increased DLA is associated with emergency revisits in dogs with CP, possibly reflecting acute flare-ups. DGGR-lipase activity was associated with the CPCSS over the follow-ups but could not differentiate disease severity.

Original languageAmerican English
Pages (from-to)437-445
Number of pages9
JournalJournal of Veterinary Internal Medicine
Volume37
Issue number2
DOIs
StatePublished - 1 Mar 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine.

Keywords

  • DGGR-lipase
  • abdominal pain
  • acute on chronic pancreatitis
  • canine

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