Vaccinia virus infection suppresses the cell microRNA machinery

Moran Grinberg, Shlomit Gilad, Eti Meiri, Asaf Levy, Ofer Isakov, Roy Ronen, Noam Shomron, Zvi Bentwich, Yonat Shemer-Avni*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

MicroRNAs are key players in the regulation of gene expression by posttranscriptional suppression. They are involved in physiological processes, and thus their deregulation may contribute to the development of diseases and progression of cancer. Virus-encoded microRNAs and microRNAs of host origin play an important role in controlling the virus life cycle and immunity. The aim of this study was to determine the effect of vaccinia virus (VACV) infection on the expression of host-encoded microRNAs. A marked general suppression of most microRNAs in the infected cells was observed within 24 hours after VACV infection of a number of cell types. We demonstrate that this suppression was associated with abrogation of expression of the Dicer1 enzyme, which is a key enzyme in the generation of microRNAs.

Original languageAmerican English
Pages (from-to)1719-1727
Number of pages9
JournalArchives of Virology
Volume157
Issue number9
DOIs
StatePublished - Sep 2012
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the Israel Science Foundation (grant no. 1375/05) and the Israel Ministry for Science, Culture, and Sport (grant no. 3-4435). The sponsor had no role in the study.

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