TY - JOUR
T1 - Valence bond all the way
T2 - From the degenerate H-exchange to cytochrome P450
AU - Shaik, Sason
PY - 2010
Y1 - 2010
N2 - This is a personalized Perspective on the development of a valence bond (VB) view of chemical reactivity (J. Am. Chem. Soc., 1981, 103, 3692) as a LEGO process whereby one constructs “reactivity objects”, such as barriers, transition states, and reaction intermediates from VB building blocks, and thereby understands and predicts chemical reactivity in a unified manner. In so doing, I have tried to give the reader a panoramic set of applications, from the simple H-exchange reaction all the way to alkane hydroxylation by cytochrome P450 (Prog. Phys. Org. Chem. 1985, 15, 197; Angew. Chem., Int. Ed., 1999, 38, 586).
AB - This is a personalized Perspective on the development of a valence bond (VB) view of chemical reactivity (J. Am. Chem. Soc., 1981, 103, 3692) as a LEGO process whereby one constructs “reactivity objects”, such as barriers, transition states, and reaction intermediates from VB building blocks, and thereby understands and predicts chemical reactivity in a unified manner. In so doing, I have tried to give the reader a panoramic set of applications, from the simple H-exchange reaction all the way to alkane hydroxylation by cytochrome P450 (Prog. Phys. Org. Chem. 1985, 15, 197; Angew. Chem., Int. Ed., 1999, 38, 586).
UR - http://www.scopus.com/inward/record.url?scp=77955108160&partnerID=8YFLogxK
U2 - 10.1039/c001372m
DO - 10.1039/c001372m
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C2 - 20574583
AN - SCOPUS:77955108160
SN - 1463-9076
VL - 12
SP - 8706
EP - 8720
JO - Physical Chemistry Chemical Physics
JF - Physical Chemistry Chemical Physics
IS - 31
ER -