Valproic acid hypersensitivity and desensitization

Ori Toker; Yuval Tal; Liran Horev; Dorit Shmoeli; Tal Gilboa

doi:10.1111/dmcn.12835

Valproic acid hypersensitivity and desensitization

Ori Toker^*
, Yuval Tal
, Liran Horev
, Dorit Shmoeli
, Tal Gilboa

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Rash, a hypersensitivity reaction, is a common cause of withdrawal from an effective antiepileptic drug (AED) in patients with epilepsy. We present a case of successful desensitization to valproic acid in a 12-year-old male with childhood absence epilepsy and a hypersensitivity reaction, whose epilepsy did not respond to other AEDs. Desensitization is a practical therapeutic solution for patients who develop a non-life-threatening hypersensitivity reaction to an AED for which there may be no substitute.

Original language	English
Pages (from-to)	1076-1078
Number of pages	3
Journal	Developmental Medicine and Child Neurology
Volume	57
Issue number	11
DOIs	https://doi.org/10.1111/dmcn.12835
State	Published - Nov 2015

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© 2015 Mac Keith Press.

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AU - Horev, Liran

AU - Shmoeli, Dorit

AU - Gilboa, Tal

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AB - Rash, a hypersensitivity reaction, is a common cause of withdrawal from an effective antiepileptic drug (AED) in patients with epilepsy. We present a case of successful desensitization to valproic acid in a 12-year-old male with childhood absence epilepsy and a hypersensitivity reaction, whose epilepsy did not respond to other AEDs. Desensitization is a practical therapeutic solution for patients who develop a non-life-threatening hypersensitivity reaction to an AED for which there may be no substitute.

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Valproic acid hypersensitivity and desensitization

Abstract

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