TY - JOUR
T1 - Variability and exclusion in host and parasite
T2 - Epigenetic regulation of Ig and var expression
AU - Fraenkel, Shira
AU - Bergman, Yehudit
PY - 2006/11/1
Y1 - 2006/11/1
N2 - The immune system generates highly diverse AgRs of different specificities from a pool of designated genomic loci, each containing large arrays of genes. Ultimately, each B or T cell expresses a receptor of a single type on its surface. Immune evasion by the malaria parasite Plasmodium falciparum is mediated by the mutually exclusive expression of a single member of the var family of genes, which encodes variant surface Ags. In this review, we discuss the similarities as well as the unique characteristics of the epigenetic mechanisms involved in the establishment of mutually exclusive expression in the immune and parasite systems.
AB - The immune system generates highly diverse AgRs of different specificities from a pool of designated genomic loci, each containing large arrays of genes. Ultimately, each B or T cell expresses a receptor of a single type on its surface. Immune evasion by the malaria parasite Plasmodium falciparum is mediated by the mutually exclusive expression of a single member of the var family of genes, which encodes variant surface Ags. In this review, we discuss the similarities as well as the unique characteristics of the epigenetic mechanisms involved in the establishment of mutually exclusive expression in the immune and parasite systems.
UR - http://www.scopus.com/inward/record.url?scp=33750353861&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.177.9.5767
DO - 10.4049/jimmunol.177.9.5767
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C2 - 17056499
AN - SCOPUS:33750353861
SN - 0022-1767
VL - 177
SP - 5767
EP - 5774
JO - Journal of Immunology
JF - Journal of Immunology
IS - 9
ER -
