The rationale behind this special issue's stepwise analysis of cross-sectoral and cross-national variations and similarities of regulatory reforms is explained. The processes of case selection and inference are clarified and justified. At the same time, the article offers a strategy for an increase in the number of cases without compromising the strength of case-oriented analysis. William Whewell's notion of consilience is employed to (a) justify the inclusion of sectoral as well as national cases; (b) justify different degrees of in-depth analysis according to the inferential role of the case in the research design; and (c) suggest a distinction in the inferential process between comparisons that enhance internal and external validity. The article concludes with a systematic examination of cross-sectoral and cross-national variations in a table that provides a "panoramic snapshot" and "holistic picture" of the combination of variations and commonalities of the cases analyzed.