Ventral pallidum cellular and pathway specificity in drug seeking

Yonatan M. Kupchik, Asheeta A. Prasad*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The ventral pallidum (VP) is central to the reinforcing effects across a variety of drugs and relapse to drug seeking. Emerging studies from animal models of reinstatement reveal a complex neurobiology of the VP that contributes to different aspects of relapse to drug seeking. This review builds on classical understanding of the VP as part of the final common pathway of relapse but also discusses the properties of the VP as an independent structure. These include VP neural anatomical subregions, cellular heterogeneity, circuitry, neurotransmitters and peptides. Collectively, this review provides a current understanding of the VP from molecular to circuit level architecture that contributes to both the appetitive and aversive symptoms of drug addiction. We show the complex neurobiology of the VP in drug seeking, emphasizing its critical role in addiction, and review strategic approaches that target the VP to reduce relapse rates.

Original languageAmerican English
Pages (from-to)373-386
Number of pages14
JournalNeuroscience and Biobehavioral Reviews
Volume131
DOIs
StatePublished - Dec 2021

Bibliographical note

Funding Information:
Preparation of this manuscript was supported by grants from the Australian Research Council ( DE170100509 ) to AAP and from the Israeli Science Foundation ( 1381/15 ) to YMK.

Publisher Copyright:
© 2021

Keywords

  • Cellular heterogeneity
  • Drug seeking
  • Neural circuits
  • Neuropeptides
  • Neurotransmitters
  • Ventral pallidum

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