Versatile communication strategies among tandem WW domain repeats

Emma Joy Dodson, Vered Fishbain-Yoskovitz, Shahar Rotem-Bamberger, Ora Schueler-Furman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Interactions mediated by short linear motifs in proteins play major roles in regulation of cellular homeostasis since their transient nature allows for easy modulation. We are still far from a full understanding and appreciation of the complex regulation patterns that can be, and are, achieved by this type of interaction. The fact that many linear-motif-binding domains occur in tandem repeats in proteins indicates that their mutual communication is used extensively to obtain complex integration of information toward regulatory decisions. This review is an attempt to overview, and classify, different ways by which two and more tandem repeats cooperate in binding to their targets, in the well-characterized family of WW domains and their corresponding polyproline ligands.

Original languageAmerican English
Pages (from-to)351-360
Number of pages10
JournalExperimental Biology and Medicine
Volume240
Issue number3
DOIs
StatePublished - 25 Mar 2015

Bibliographical note

Publisher Copyright:
© 2015 by the Society for Experimental Biology and Medicine

Keywords

  • WW domain
  • WW domain containing oxidoreductase
  • Yes-associated protein
  • cooperative binding
  • peptide-mediated interactions
  • protein domain repeats
  • regulation of signaling

Fingerprint

Dive into the research topics of 'Versatile communication strategies among tandem WW domain repeats'. Together they form a unique fingerprint.

Cite this