Very high birth weight of offspring is associated with an increased risk of leukemia in their mothers: Results of a population-based cohort study

Ora Paltiel; Rebecca Yanetz; Ronit Calderon-Margalit; Orly Manor; Nir Sharon; Susan Harlap; Yehiel Friedlander

doi:10.1016/j.leukres.2008.04.003

Very high birth weight of offspring is associated with an increased risk of leukemia in their mothers: Results of a population-based cohort study

Ora Paltiel^*, Rebecca Yanetz, Ronit Calderon-Margalit, Orly Manor, Nir Sharon, Susan Harlap, Yehiel Friedlander

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Although the association between birth weight and childhood leukemia is well described, the relation between a child's birth weight and parental risk of leukemia is unknown. We linked data from the Jerusalem Perinatal Study to the Israel Cancer Registry to ascertain the incidence of leukemia in mothers and fathers in relation to their offspring's birth weight. Birth weight ≥4500 g in any of the offspring was associated with a >3-fold risk of leukemia in mothers, but not fathers. Potential mechanisms include shared exposures of high birth weight infants and their mothers, possibly to radiation or growth factors, or genetic pathways leading to both high birth weight and leukemia.

Original language	English
Pages (from-to)	1709-1714
Number of pages	6
Journal	Leukemia Research
Volume	32
Issue number	11
DOIs	https://doi.org/10.1016/j.leukres.2008.04.003
State	Published - Nov 2008
Externally published	Yes

Keywords

Birth weight
Intergenerational effects
Leukemia
Macrosomia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2008.04.003

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abstract = "Although the association between birth weight and childhood leukemia is well described, the relation between a child's birth weight and parental risk of leukemia is unknown. We linked data from the Jerusalem Perinatal Study to the Israel Cancer Registry to ascertain the incidence of leukemia in mothers and fathers in relation to their offspring's birth weight. Birth weight ≥4500 g in any of the offspring was associated with a >3-fold risk of leukemia in mothers, but not fathers. Potential mechanisms include shared exposures of high birth weight infants and their mothers, possibly to radiation or growth factors, or genetic pathways leading to both high birth weight and leukemia.",

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AU - Paltiel, Ora

AU - Yanetz, Rebecca

AU - Calderon-Margalit, Ronit

AU - Manor, Orly

AU - Sharon, Nir

AU - Harlap, Susan

AU - Friedlander, Yehiel

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AB - Although the association between birth weight and childhood leukemia is well described, the relation between a child's birth weight and parental risk of leukemia is unknown. We linked data from the Jerusalem Perinatal Study to the Israel Cancer Registry to ascertain the incidence of leukemia in mothers and fathers in relation to their offspring's birth weight. Birth weight ≥4500 g in any of the offspring was associated with a >3-fold risk of leukemia in mothers, but not fathers. Potential mechanisms include shared exposures of high birth weight infants and their mothers, possibly to radiation or growth factors, or genetic pathways leading to both high birth weight and leukemia.

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KW - Intergenerational effects

KW - Leukemia

KW - Macrosomia

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ER -

Very high birth weight of offspring is associated with an increased risk of leukemia in their mothers: Results of a population-based cohort study

Abstract

Keywords

UN SDGs

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