Neural cells can be derived either from pluripotent or adult stem cells via differentiation or by transdifferentiation from other cell types with the aid of tissue regulators. We compared the chromosomal stability of over 500 neural cell samples from human and mouse with virtual karyotyping (e-karyotyping). We detected notable genomic instability in cells derived from pluripotent or adult stem cells, but surprisingly, transdifferentiated cells seemed more chromosomally stable, except if they were reprogrammed using pluripotency factors.
Bibliographical noteFunding Information:
The authors would like to thank Neta Nudel, Ido Sagi and Yishai Avior for critically reading the manuscript. N.B. is the Herbert Cohn Chair in Cancer Research. This work was partially supported by the Israel Science Foundation (grant no. 269/12). U.B.-D. is an EMBO Long-Term Fellow.
© 2014 Elsevier Inc.