Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells

Uri Weissbein; Uri Ben-David; Nissim Benvenisty

doi:10.1016/j.stem.2014.10.018

Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells

Uri Weissbein, Uri Ben-David, Nissim Benvenisty^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Comment/debate

21 Scopus citations

Abstract

Neural cells can be derived either from pluripotent or adult stem cells via differentiation or by transdifferentiation from other cell types with the aid of tissue regulators. We compared the chromosomal stability of over 500 neural cell samples from human and mouse with virtual karyotyping (e-karyotyping). We detected notable genomic instability in cells derived from pluripotent or adult stem cells, but surprisingly, transdifferentiated cells seemed more chromosomally stable, except if they were reprogrammed using pluripotency factors.

Original language	American English
Pages (from-to)	687-691
Number of pages	5
Journal	Cell Stem Cell
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2014.10.018
State	Published - 4 Dec 2014

Bibliographical note

Funding Information:
The authors would like to thank Neta Nudel, Ido Sagi and Yishai Avior for critically reading the manuscript. N.B. is the Herbert Cohn Chair in Cancer Research. This work was partially supported by the Israel Science Foundation (grant no. 269/12). U.B.-D. is an EMBO Long-Term Fellow.

Publisher Copyright:
© 2014 Elsevier Inc.

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abstract = "Neural cells can be derived either from pluripotent or adult stem cells via differentiation or by transdifferentiation from other cell types with the aid of tissue regulators. We compared the chromosomal stability of over 500 neural cell samples from human and mouse with virtual karyotyping (e-karyotyping). We detected notable genomic instability in cells derived from pluripotent or adult stem cells, but surprisingly, transdifferentiated cells seemed more chromosomally stable, except if they were reprogrammed using pluripotency factors.",

author = "Uri Weissbein and Uri Ben-David and Nissim Benvenisty",

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doi = "10.1016/j.stem.2014.10.018",

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AU - Ben-David, Uri

AU - Benvenisty, Nissim

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N2 - Neural cells can be derived either from pluripotent or adult stem cells via differentiation or by transdifferentiation from other cell types with the aid of tissue regulators. We compared the chromosomal stability of over 500 neural cell samples from human and mouse with virtual karyotyping (e-karyotyping). We detected notable genomic instability in cells derived from pluripotent or adult stem cells, but surprisingly, transdifferentiated cells seemed more chromosomally stable, except if they were reprogrammed using pluripotency factors.

AB - Neural cells can be derived either from pluripotent or adult stem cells via differentiation or by transdifferentiation from other cell types with the aid of tissue regulators. We compared the chromosomal stability of over 500 neural cell samples from human and mouse with virtual karyotyping (e-karyotyping). We detected notable genomic instability in cells derived from pluripotent or adult stem cells, but surprisingly, transdifferentiated cells seemed more chromosomally stable, except if they were reprogrammed using pluripotency factors.

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Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells

Abstract

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