Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells

Uri Weissbein; Uri Ben-David; Nissim Benvenisty

doi:10.1016/j.stem.2014.10.018

Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells

Uri Weissbein, Uri Ben-David, Nissim Benvenisty^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Comment/debate

23 Scopus citations

Abstract

Neural cells can be derived either from pluripotent or adult stem cells via differentiation or by transdifferentiation from other cell types with the aid of tissue regulators. We compared the chromosomal stability of over 500 neural cell samples from human and mouse with virtual karyotyping (e-karyotyping). We detected notable genomic instability in cells derived from pluripotent or adult stem cells, but surprisingly, transdifferentiated cells seemed more chromosomally stable, except if they were reprogrammed using pluripotency factors.

Original language	English
Pages (from-to)	687-691
Number of pages	5
Journal	Cell Stem Cell
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2014.10.018
State	Published - 4 Dec 2014

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© 2014 Elsevier Inc.

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Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells

Abstract

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