Virulence and drug resistance in malaria parasites

Wilfred D. Stein; Cecilia P. Sanchez; Michael Lanzer

doi:10.1016/j.pt.2009.07.003

Virulence and drug resistance in malaria parasites

Wilfred D. Stein^*, Cecilia P. Sanchez, Michael Lanzer

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

Virulence and drug resistance are traits that pathogens can acquire independently, albeit these traits can influence each other. A recent publication has reported on the co-evolution of virulence and pyrimethamine resistance in malaria parasites. Here, we discuss this finding in the context of the folate biosynthesis pathway and explain how mutational changes in this pathway can affect both parasite replication rates and the development of drug resistance.

Original language	English
Pages (from-to)	441-443
Number of pages	3
Journal	Trends in Parasitology
Volume	25
Issue number	10
DOIs	https://doi.org/10.1016/j.pt.2009.07.003
State	Published - Oct 2009

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10.1016/j.pt.2009.07.003

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title = "Virulence and drug resistance in malaria parasites",

abstract = "Virulence and drug resistance are traits that pathogens can acquire independently, albeit these traits can influence each other. A recent publication has reported on the co-evolution of virulence and pyrimethamine resistance in malaria parasites. Here, we discuss this finding in the context of the folate biosynthesis pathway and explain how mutational changes in this pathway can affect both parasite replication rates and the development of drug resistance.",

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AB - Virulence and drug resistance are traits that pathogens can acquire independently, albeit these traits can influence each other. A recent publication has reported on the co-evolution of virulence and pyrimethamine resistance in malaria parasites. Here, we discuss this finding in the context of the folate biosynthesis pathway and explain how mutational changes in this pathway can affect both parasite replication rates and the development of drug resistance.

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Virulence and drug resistance in malaria parasites

Abstract

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