Abstract
The replication of active and inactivated influenza viruses in Daudi lymphoma cells was studied by immunofluorescence and electron microscopy. Transmission electron microscopic studies revealed that both the active and the heat-inactivated X47 virus penetrated into the cells. Only the active X47 (XA) virus replicated completely in Daudi cells and produced new viral particles by budding. The formalin-treated X47 virus did not damage or change the cells, and although the viral particles remained adsorbed to the cells, there was little penetration. The heat inactivated X47 virus was visualized as large aggregates of particles adsorbed to the cell surface by electron microscopy.
Original language | English |
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Pages (from-to) | 1687-1693 |
Number of pages | 7 |
Journal | Scanning Electron Microscopy |
Volume | v |
State | Published - 1985 |