VISUALIZATION OF THE FATE OF INACTIVE INFLUENZA VIRUSES IN DAUDI CELLS BY ELECTRON MICROSCOPY.

Gilda Weil-Hillman*, Haim Gamliel, Adam Friedmann, Zichria Zakay-Rones

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The replication of active and inactivated influenza viruses in Daudi lymphoma cells was studied by immunofluorescence and electron microscopy. Transmission electron microscopic studies revealed that both the active and the heat-inactivated X47 virus penetrated into the cells. Only the active X47 (XA) virus replicated completely in Daudi cells and produced new viral particles by budding. The formalin-treated X47 virus did not damage or change the cells, and although the viral particles remained adsorbed to the cells, there was little penetration. The heat inactivated X47 virus was visualized as large aggregates of particles adsorbed to the cell surface by electron microscopy.

Original languageEnglish
Pages (from-to)1687-1693
Number of pages7
JournalScanning Electron Microscopy
Volumev
StatePublished - 1985

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