Vitamin A and the epigenome

Shimrit Bar-El Dadon, Ram Reifen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


The epigenetic phenomena refer to heritable changes in gene expression other than those in the DNA sequence, such as DNA methylation and histone modifications. Major research progress in the last few years has provided further proof that environmental factors, including diet and nutrition, can influence physiologic and pathologic processes through epigenetic alterations, which in turn influence gene expression. This influence is termed nutritional epigenetics, and one prominent example is the regulation of gene transcription by vitamin A through interaction to its nuclear receptor. Vitamin A is critical throughout life. Together with its derivatives, it regulates diverse processes including reproduction, embryogenesis, vision, growth, cellular differentiation and proliferation, maintenance of epithelial cellular integrity and immune function. Here we review the epigenetic role of vitamin A in cancer, stem cells differentiation, proliferation, and immunity. The data presented here show that retinoic acid is a potent agent capable of inducing alterations in epigenetic modifications that produce various effects on the phenotype. Medical benefits of vitamin A as an epigenetic modulator, especially with respect to its chronic use as nutritional supplement, should rely on our further understanding of its epigenetic effects during health and disease, as well as through different generations.

Original languageAmerican English
Pages (from-to)2404-2411
Number of pages8
JournalCritical Reviews in Food Science and Nutrition
Issue number11
StatePublished - 24 Jul 2017

Bibliographical note

Publisher Copyright:
© 2017 Taylor & Francis Group, LLC.


  • Vitamin A
  • epigenetics
  • nutrition
  • nutritional epigenetics


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