VMAT structures reveal exciting targets for drug development

Shimon Schuldiner; Lucy R. Forrest

doi:10.1016/j.tips.2024.02.004

VMAT structures reveal exciting targets for drug development

Shimon Schuldiner^*
, Lucy R. Forrest

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Vesicular monoamine transporter (VMAT)-2 has a crucial role in the neurotransmission of biogenic amines. Recently, Dalton et al., Pidathala et al., Wu et al., and Wang et al. individually reported cryo-electron microscopy (EM) structures of human VMAT2, offering opportunities for developing improved therapeutics and deep insights into the functioning of this protein.

Original language	English
Pages (from-to)	385-387
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	45
Issue number	5
DOIs	https://doi.org/10.1016/j.tips.2024.02.004
State	Published - May 2024

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Ltd

Keywords

cryo-EM structure
neurotransmission
neurotransmitter transporter
synaptic vesicles

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10.1016/j.tips.2024.02.004

Cite this

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abstract = "Vesicular monoamine transporter (VMAT)-2 has a crucial role in the neurotransmission of biogenic amines. Recently, Dalton et al., Pidathala et al., Wu et al., and Wang et al. individually reported cryo-electron microscopy (EM) structures of human VMAT2, offering opportunities for developing improved therapeutics and deep insights into the functioning of this protein.",

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note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = may,

doi = "10.1016/j.tips.2024.02.004",

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KW - cryo-EM structure

KW - neurotransmission

KW - neurotransmitter transporter

KW - synaptic vesicles

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VMAT structures reveal exciting targets for drug development

Abstract

Bibliographical note

Keywords

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