Vorticella-a model for chemopharmacodynamic action on smooth muscle

M. Maran, R. Himelstein, S. Dikstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

1. 1. Vorticella contracture is a unique model for studying non-specific chemical stimulus (chemopharmacodynamic action). 2. 2. The classic agonists have no activity up to 1 mM, except for low sensitivity towards nicotine. We could not find evidence for the presence of the adenyl cyclase or the prostaglandin systems. 3. 3. On the other hand, the usual non-specific stimulators are active. They include oxidizing agents with low redox potential, such as phenazine methosulphate or menadione; glutatione oxidizing agents, such as diamide, KCN, N-tert.-butyl-5-methylisoxazolium. Papaverine is inhibitory, whereas ouabain has no effect on the phenazine methosulphate-induced contractures.

Original languageEnglish
Pages (from-to)363-370
Number of pages8
JournalComparative and General Pharmacology
Volume3
Issue number11
DOIs
StatePublished - Sep 1972

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