Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor

Naama Karu, Ram Reifen, Zohar Kerem*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

122 Scopus citations


Roots of the herb Panax ginseng are known to contain high levels of bioactive saponins. Here, we isolated saponins from ginseng root powder and studied their inhibitory effect on the absorption of dietary fat in male Balb/c mice. Consumption of ginseng saponins suppressed the expected increase in body weight and plasma triacylglycerols, following a high-fat diet and observed higher intake. Consumption of ginseng saponins had no effect on the concentration of the total plasma cholesterol in both chow and high-fat diets in mice. The mode by which saponins from ginseng inhibit lipid metabolism was assessed as the in vitro inhibition of pancreatic lipase: Ginseng saponin inhibited pancreatic lipase with an apparent IC50 value of 500 μg/mL. Our results suggest that the anti-obesity and hypolipidemic effects of Ginseng in high-fat diet-treated mice were attributed to the isolated saponin fraction. These metabolic effects of the ginseng saponins may be mediated by inhibition of pancreatic lipase activity.

Original languageAmerican English
Pages (from-to)2824-2828
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Issue number8
StatePublished - 18 Apr 2007


  • Blood lipids
  • Cholesterol
  • Dietary fat
  • Ginseng
  • Obesity
  • Pancreatic lipase
  • Saponin
  • Triacylglycerol


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