West nile virions aligned along myelin lamellae in organotypic spinal cord cultures

A. Shahar*, S. Lustig, Y. Akov, Y. David, P. Schneider, A. Friedmann, R. Levin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Organtypic spinal cord cultures infected with West Nile Virus (WNV) exhibited a remarkable arrangement of virions among lamellae of the myelin sheath. Virions were first observed in neurons and only at day 4 after infection appeared within the myelin lamellae. Virions were observed only in the central myelin, aligned along the interperiod lines and therefor attached to the outer side of the oligodendrocyte membrane. In spite of this peculiar location of the virions, their presence was not associated with severe damage to the axon or to the myelin sheath. The causes of the formation of this viral pattern, its morphological features, and the role which it might have in viral infection in vivo are considered.

Original languageEnglish
Pages (from-to)495-500
Number of pages6
JournalJournal of Neuroscience Research
Volume26
Issue number4
DOIs
StatePublished - Aug 1990

Keywords

  • interperiod lines
  • myelin sheath
  • West Nile virus

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