When cells get stressed: An integrative view of cellular senescence

Ittai Ben-Porath, Robert A. Weinberg*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

337 Scopus citations

Abstract

Cells entering a state of senescence undergo a permanent cell cycle arrest, accompanied by a set of functional and morphological changes. Senescence of cells occurs following an extended period of proliferation in culture or in response to various physiologic stresses, yet little is known about the role this phenomenon plays in vivo. The study of senescence has focused largely on its hypothesized role as a barrier to extended cell division, governed by a division-counting mechanism in the form of telomere length. Here, we discuss the biological functions of cellular senescence and suggest that it should be viewed in terms of its role as a general cellular stress response program, rather than strictly as a barrier to unlimited cycles of cell growth and division. We also discuss the relative roles played by telomere shortening and telomere uncapping in the induction of senescence.

Original languageAmerican English
Pages (from-to)8-13
Number of pages6
JournalJournal of Clinical Investigation
Volume113
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

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