When do metal complexes protect the biological system from superoxide toxicity and when do they enhance it?

Gidon Czapski*, Sara Goldstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Many copper and iron complexes can be reduced by O-2 as well as by H2O2. According to the rates of reduction and the concentration of O-2 and H2O2, the metal complexes may serve either as catalyst of O-2 dismutation or as catalysts of the reaction between O-2 and H2O2 to form OH' radical (Haber-Weiss reaction). Various factors which influence whether metal complexes protect the biological systems from superoxide toxicity or enhance it are discussed.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalFree Radical Research
Volume1
Issue number3
DOIs
StatePublished - 1986

Keywords

  • 'Haber-Weiss' Reaction
  • Copper Complexes
  • SOD Activity
  • Superoxide Toxicity

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