Where are things inside a bacterial cell?

Sutharsan Govindarajan, Orna Amster-Choder

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Bacterial cells are intricately organized, despite the lack of membrane-bounded organelles. The extremely crowded cytoplasm promotes macromolecular self-assembly and formation of distinct subcellular structures, which perform specialized functions. For example, the cell poles act as hubs for signal transduction complexes, thus providing a platform for the coordination of optimal cellular responses to environmental cues. Distribution of macromolecules is mostly mediated via specialized transport machineries, including the MreB cytoskeleton. Recent evidence shows that RNAs also specifically localize within bacterial cells, raising the possibility that gene expression is spatially organized. Here we review the current understanding of where things are in bacterial cells and discuss emerging questions that need to be addressed in the future.

Original languageAmerican English
Pages (from-to)83-90
Number of pages8
JournalCurrent Opinion in Microbiology
StatePublished - 1 Oct 2016

Bibliographical note

Funding Information:
We thank all past and present members of the laboratory for fruitful discussions over the years. This work was supported by the Israel Science Foundation (ISF) founded by the Israel Academy of Sciences and Humanities and the Deutsch-Israeli Project Cooperation (DIP).

Publisher Copyright:
© 2016 Elsevier Ltd


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