Where microbiology meets microengineering: Design and applications of reporter bacteria

Jan Roelof Van Der Meer, Shimshon Belkin

Research output: Contribution to journalReview articlepeer-review

440 Scopus citations

Abstract

Bacteria have long been the targets for genetic manipulation, but more recently they have been synthetically designed to carry out specific tasks. Among the simplest of these tasks is chemical compound and toxicity detection coupled to the production of a quantifiable reporter signal. In this Review, we describe the current design of bacterial bioreporters and their use in a range of assays to measure the presence of harmful chemicals in water, air, soil, food or biological specimens. New trends for integrating synthetic biology and microengineering into the design of bacterial bioreporter platforms are also highlighted.

Original languageEnglish
Pages (from-to)511-522
Number of pages12
JournalNature Reviews Microbiology
Volume8
Issue number7
DOIs
StatePublished - Jun 2010

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