TY - JOUR
T1 - Where microbiology meets microengineering
T2 - Design and applications of reporter bacteria
AU - Van Der Meer, Jan Roelof
AU - Belkin, Shimshon
PY - 2010/6
Y1 - 2010/6
N2 - Bacteria have long been the targets for genetic manipulation, but more recently they have been synthetically designed to carry out specific tasks. Among the simplest of these tasks is chemical compound and toxicity detection coupled to the production of a quantifiable reporter signal. In this Review, we describe the current design of bacterial bioreporters and their use in a range of assays to measure the presence of harmful chemicals in water, air, soil, food or biological specimens. New trends for integrating synthetic biology and microengineering into the design of bacterial bioreporter platforms are also highlighted.
AB - Bacteria have long been the targets for genetic manipulation, but more recently they have been synthetically designed to carry out specific tasks. Among the simplest of these tasks is chemical compound and toxicity detection coupled to the production of a quantifiable reporter signal. In this Review, we describe the current design of bacterial bioreporters and their use in a range of assays to measure the presence of harmful chemicals in water, air, soil, food or biological specimens. New trends for integrating synthetic biology and microengineering into the design of bacterial bioreporter platforms are also highlighted.
UR - http://www.scopus.com/inward/record.url?scp=77953622209&partnerID=8YFLogxK
U2 - 10.1038/nrmicro2392
DO - 10.1038/nrmicro2392
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C2 - 20514043
AN - SCOPUS:77953622209
SN - 1740-1526
VL - 8
SP - 511
EP - 522
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 7
ER -