TY - JOUR
T1 - Whole blood microRNA expression associated with stroke
T2 - Results from the Framingham Heart Study
AU - Salinas, Joel
AU - Lin, Honghuang
AU - Aparico, Hugo J.
AU - Huan, Tianxiao
AU - Liu, Chunyu
AU - Rong, Jian
AU - Beiser, Alexa
AU - Himali, Jayandra J.
AU - Freedman, Jane E.
AU - Larson, Martin G.
AU - Rosand, Jonathan
AU - Soreq, Hermona
AU - Levy, Daniel
AU - Seshadri, Sudha
N1 - Publisher Copyright:
© 2019 Salinas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Emerging evidence suggests microRNAs (miRNAs) may play an important role in explaining variation in stroke risk and recovery in humans, yet there are still few longitudinal studies examining the association between whole blood miRNAs and stroke. Accounting for multiple testing and adjusting for potentially confounding technical and clinical variables, here we show that whole blood miR-574-3p expression was significantly lower in participants with chronic stroke compared to non-cases. To explore the functional relevance of our findings, we analyzed miRNA-mRNA whole blood co-expression, pathway enrichment, and brain tissue gene expression. Results suggest miR-574-3p is involved in neurometabolic and chronic neuronal injury response pathways, including brain gene expression of DBNDD2 and ELOVL1. These results suggest miR-574-3p plays a role in regulating chronic brain and systemic cellular response to stroke and thus may implicate miR-574-3p as a partial mediator of long-term stroke outcomes.
AB - Emerging evidence suggests microRNAs (miRNAs) may play an important role in explaining variation in stroke risk and recovery in humans, yet there are still few longitudinal studies examining the association between whole blood miRNAs and stroke. Accounting for multiple testing and adjusting for potentially confounding technical and clinical variables, here we show that whole blood miR-574-3p expression was significantly lower in participants with chronic stroke compared to non-cases. To explore the functional relevance of our findings, we analyzed miRNA-mRNA whole blood co-expression, pathway enrichment, and brain tissue gene expression. Results suggest miR-574-3p is involved in neurometabolic and chronic neuronal injury response pathways, including brain gene expression of DBNDD2 and ELOVL1. These results suggest miR-574-3p plays a role in regulating chronic brain and systemic cellular response to stroke and thus may implicate miR-574-3p as a partial mediator of long-term stroke outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85070300246&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0219261
DO - 10.1371/journal.pone.0219261
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 31393881
AN - SCOPUS:85070300246
SN - 1932-6203
VL - 14
JO - PLoS ONE
JF - PLoS ONE
IS - 8
M1 - e0219261
ER -
