Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study

Joel Salinas; Honghuang Lin; Hugo J. Aparico; Tianxiao Huan; Chunyu Liu; Jian Rong; Alexa Beiser; Jayandra J. Himali; Jane E. Freedman; Martin G. Larson; Jonathan Rosand; Hermona Soreq; Daniel Levy; Sudha Seshadri

doi:10.1371/journal.pone.0219261

Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study

Joel Salinas^*
, Honghuang Lin
, Hugo J. Aparico
, Tianxiao Huan
, Chunyu Liu
, Jian Rong
, Alexa Beiser
, Jayandra J. Himali
, Jane E. Freedman
, Martin G. Larson
, Jonathan Rosand
, Hermona Soreq
, Daniel Levy
, Sudha Seshadri

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Emerging evidence suggests microRNAs (miRNAs) may play an important role in explaining variation in stroke risk and recovery in humans, yet there are still few longitudinal studies examining the association between whole blood miRNAs and stroke. Accounting for multiple testing and adjusting for potentially confounding technical and clinical variables, here we show that whole blood miR-574-3p expression was significantly lower in participants with chronic stroke compared to non-cases. To explore the functional relevance of our findings, we analyzed miRNA-mRNA whole blood co-expression, pathway enrichment, and brain tissue gene expression. Results suggest miR-574-3p is involved in neurometabolic and chronic neuronal injury response pathways, including brain gene expression of DBNDD2 and ELOVL1. These results suggest miR-574-3p plays a role in regulating chronic brain and systemic cellular response to stroke and thus may implicate miR-574-3p as a partial mediator of long-term stroke outcomes.

Original language	English
Article number	e0219261
Journal	PLoS ONE
Volume	14
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0219261
State	Published - 1 Aug 2019

Bibliographical note

Publisher Copyright:
© 2019 Salinas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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title = "Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study",

abstract = "Emerging evidence suggests microRNAs (miRNAs) may play an important role in explaining variation in stroke risk and recovery in humans, yet there are still few longitudinal studies examining the association between whole blood miRNAs and stroke. Accounting for multiple testing and adjusting for potentially confounding technical and clinical variables, here we show that whole blood miR-574-3p expression was significantly lower in participants with chronic stroke compared to non-cases. To explore the functional relevance of our findings, we analyzed miRNA-mRNA whole blood co-expression, pathway enrichment, and brain tissue gene expression. Results suggest miR-574-3p is involved in neurometabolic and chronic neuronal injury response pathways, including brain gene expression of DBNDD2 and ELOVL1. These results suggest miR-574-3p plays a role in regulating chronic brain and systemic cellular response to stroke and thus may implicate miR-574-3p as a partial mediator of long-term stroke outcomes.",

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AU - Liu, Chunyu

AU - Rong, Jian

AU - Beiser, Alexa

AU - Himali, Jayandra J.

AU - Freedman, Jane E.

AU - Larson, Martin G.

AU - Rosand, Jonathan

AU - Soreq, Hermona

AU - Levy, Daniel

AU - Seshadri, Sudha

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N2 - Emerging evidence suggests microRNAs (miRNAs) may play an important role in explaining variation in stroke risk and recovery in humans, yet there are still few longitudinal studies examining the association between whole blood miRNAs and stroke. Accounting for multiple testing and adjusting for potentially confounding technical and clinical variables, here we show that whole blood miR-574-3p expression was significantly lower in participants with chronic stroke compared to non-cases. To explore the functional relevance of our findings, we analyzed miRNA-mRNA whole blood co-expression, pathway enrichment, and brain tissue gene expression. Results suggest miR-574-3p is involved in neurometabolic and chronic neuronal injury response pathways, including brain gene expression of DBNDD2 and ELOVL1. These results suggest miR-574-3p plays a role in regulating chronic brain and systemic cellular response to stroke and thus may implicate miR-574-3p as a partial mediator of long-term stroke outcomes.

AB - Emerging evidence suggests microRNAs (miRNAs) may play an important role in explaining variation in stroke risk and recovery in humans, yet there are still few longitudinal studies examining the association between whole blood miRNAs and stroke. Accounting for multiple testing and adjusting for potentially confounding technical and clinical variables, here we show that whole blood miR-574-3p expression was significantly lower in participants with chronic stroke compared to non-cases. To explore the functional relevance of our findings, we analyzed miRNA-mRNA whole blood co-expression, pathway enrichment, and brain tissue gene expression. Results suggest miR-574-3p is involved in neurometabolic and chronic neuronal injury response pathways, including brain gene expression of DBNDD2 and ELOVL1. These results suggest miR-574-3p plays a role in regulating chronic brain and systemic cellular response to stroke and thus may implicate miR-574-3p as a partial mediator of long-term stroke outcomes.

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Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study

Abstract

Bibliographical note

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