Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking

Daniel Maxim Iascone; Yujie Li; Uygar Sümbül; Michael Doron; Hanbo Chen; Valentine Andreu; Finola Goudy; Heike Blockus; Larry F. Abbott; Idan Segev; Hanchuan Peng; Franck Polleux

doi:10.1016/j.neuron.2020.02.015

Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking

Daniel Maxim Iascone
, Yujie Li
, Uygar Sümbül
, Michael Doron
, Hanbo Chen
, Valentine Andreu
, Finola Goudy
, Heike Blockus
, Larry F. Abbott
, Idan Segev^*
, Hanchuan Peng
, Franck Polleux

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

Iascone et al. developed an open source software within Vaa3D to map the distribution and morphology of synapses across the dendritic arbor of mouse layer 2/3 cortical PNs. Reconstruction of >90,000 synapses and computational modeling reveal several scales of organization, including domain-specific local balance between E and I synaptic distribution.

Original language	English
Pages (from-to)	566-578.e8
Journal	Neuron
Volume	106
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2020.02.015
State	Published - 20 May 2020

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© 2020 Elsevier Inc.

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AU - Sümbül, Uygar

AU - Doron, Michael

AU - Chen, Hanbo

AU - Andreu, Valentine

AU - Goudy, Finola

AU - Blockus, Heike

AU - Abbott, Larry F.

AU - Segev, Idan

AU - Peng, Hanchuan

AU - Polleux, Franck

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Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking

Abstract

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