Why it is important to study human–monkey embryonic chimeras in a dish

Alejandro De Los Angeles; Alan Regenberg; Victoria Mascetti; Nissim Benvenisty; George Church; Hongkui Deng; Juan Carlos Izpisua Belmonte; Weizhi Ji; Julian Koplin; Yuin Han Loh; Yuyu Niu; Duanqing Pei; Martin Pera; Nam Pho; Carlos Pinzon-Arteaga; Mitinori Saitou; Jose C.R. Silva; Tan Tao; Alan Trounson; Tushar Warrier; Elias T. Zambidis

doi:10.1038/s41592-022-01571-7

Why it is important to study human–monkey embryonic chimeras in a dish

Alejandro De Los Angeles^*, Alan Regenberg, Victoria Mascetti, Nissim Benvenisty, George Church, Hongkui Deng, Juan Carlos Izpisua Belmonte, Weizhi Ji, Julian Koplin, Yuin Han Loh, Yuyu Niu, Duanqing Pei, Martin Pera, Nam Pho, Carlos Pinzon-Arteaga, Mitinori Saitou, Jose C.R. Silva, Tan Tao, Alan Trounson, Tushar WarrierElias T. Zambidis

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

The study of human–animal chimeras is fraught with technical and ethical challenges. In this Comment, we discuss the importance and future of human–monkey chimera research within the context of current scientific and regulatory obstacles.

Original language	English
Pages (from-to)	914-919
Number of pages	6
Journal	Nature Methods
Volume	19
Issue number	8
DOIs	https://doi.org/10.1038/s41592-022-01571-7
State	Published - Aug 2022

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De Los Angeles, A., Regenberg, A., Mascetti, V., Benvenisty, N., Church, G., Deng, H., Izpisua Belmonte, J. C., Ji, W., Koplin, J., Loh, Y. H., Niu, Y., Pei, D., Pera, M., Pho, N., Pinzon-Arteaga, C., Saitou, M., Silva, J. C. R., Tao, T., Trounson, A., ... Zambidis, E. T. (2022). Why it is important to study human–monkey embryonic chimeras in a dish. Nature Methods, 19(8), 914-919. https://doi.org/10.1038/s41592-022-01571-7

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abstract = "The study of human–animal chimeras is fraught with technical and ethical challenges. In this Comment, we discuss the importance and future of human–monkey chimera research within the context of current scientific and regulatory obstacles.",

author = "{De Los Angeles}, Alejandro and Alan Regenberg and Victoria Mascetti and Nissim Benvenisty and George Church and Hongkui Deng and {Izpisua Belmonte}, {Juan Carlos} and Weizhi Ji and Julian Koplin and Loh, {Yuin Han} and Yuyu Niu and Duanqing Pei and Martin Pera and Nam Pho and Carlos Pinzon-Arteaga and Mitinori Saitou and Silva, {Jose C.R.} and Tan Tao and Alan Trounson and Tushar Warrier and Zambidis, {Elias T.}",

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De Los Angeles, A, Regenberg, A, Mascetti, V, Benvenisty, N, Church, G, Deng, H, Izpisua Belmonte, JC, Ji, W, Koplin, J, Loh, YH, Niu, Y, Pei, D, Pera, M, Pho, N, Pinzon-Arteaga, C, Saitou, M, Silva, JCR, Tao, T, Trounson, A, Warrier, T & Zambidis, ET 2022, 'Why it is important to study human–monkey embryonic chimeras in a dish', Nature Methods, vol. 19, no. 8, pp. 914-919. https://doi.org/10.1038/s41592-022-01571-7

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AU - De Los Angeles, Alejandro

AU - Regenberg, Alan

AU - Mascetti, Victoria

AU - Benvenisty, Nissim

AU - Church, George

AU - Deng, Hongkui

AU - Izpisua Belmonte, Juan Carlos

AU - Ji, Weizhi

AU - Koplin, Julian

AU - Loh, Yuin Han

AU - Niu, Yuyu

AU - Pei, Duanqing

AU - Pera, Martin

AU - Pho, Nam

AU - Pinzon-Arteaga, Carlos

AU - Saitou, Mitinori

AU - Silva, Jose C.R.

AU - Tao, Tan

AU - Trounson, Alan

AU - Warrier, Tushar

AU - Zambidis, Elias T.

PY - 2022/8

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Why it is important to study human–monkey embryonic chimeras in a dish

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