Wingful, an extracellular feedback inhibitor of Wingless

Offer Gerlitz, Konrad Basler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


Secreted peptide signals control many fundamental processes during animal development. Proper responses to these signals require cognate inducible feedback antagonists. Here we report the identification of a novel Drosophila Wingless (Wg) target gene, wingful (wf), and show that it encodes a potent extracellular feedback inhibitor of Wg. In contrast to the cytoplasmic protein Naked cuticle (Nkd), the only known Wg feedback antagonist, Wf functions during larval stages, when Nkd function is dispensable. We propose that Wf may provide feedback control for the long-range morphogen activities of Wg.

Original languageAmerican English
Pages (from-to)1055-1059
Number of pages5
JournalGenes and Development
Issue number9
StatePublished - 1 May 2002
Externally publishedYes


  • Negative feedback control
  • Pattern formation
  • Wingless signaling


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