Wnt/[beta]-catenin signaling in vertebrate posterior neural development

Yaniv M Elkouby, Dale Frank

Research output: Book/ReportBook


The Wnt/[beta]-catenin signaling pathway is a key regulator of cell fate specification, differentiation, and growth in multiple systems throughout the animal kingdom. In vertebrate posterior neural development, Wnt/[beta]-catenin signaling controls this complex multistep process. It initially induces the posterior regions of the nervous system, including the mid-hindbrain border, hindbrain, spinal cord and neural crest, and then subsequently fine-tunes the pattern of each region and determines the different cell fates within them. In this review, we explore the function of the Wnt/[beta]-catenin pathway during the formation of these specific posterior neural regions. We have examined the important transcriptional targets of the Wnt/[beta]-catenin pathway acting downstream to mediate its morphogenetic activity. Different regulatory networks are activated in different posterior neural regions, and these networks induce specific neural cell types in each region. Eludidating how each of these networks specify different cell fates is crucial for understanding the basic tenets of how Wnt morphogenetic activity induces the posterior nervous system during the earliest stages of vertebrate development.
Original languageEnglish
Place of PublicationSan Rafael, Calif
PublisherMorgan & Claypool
Number of pages77
ISBN (Electronic)1615040552, 9781615040551
ISBN (Print)1615040544, 9781615040544
StatePublished - 2010

Publication series

NameNCBI Bookshelf
PublisherMorgan & Claypool
Volume# 4


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