World Workshop on Oral Medicine VI: Clinical implications of medication-induced salivary gland dysfunction

Ardita Aliko, Andy Wolff*, Colin Dawes, Doron Aframian, Gordon Proctor, Jörgen Ekström, Nagamani Narayana, Alessandro Villa, Ying Wai Sia, Revan Kumar Joshi, Richard McGowan, Siri Beier Jensen, A. Ross Kerr, Anne Marie Lynge Pedersen, Arjan Vissink

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    71 Scopus citations


    Objective This study aimed to systematically review the available literature on the clinical implications of medication-induced salivary gland dysfunction (MISGD). Study Design The systematic review was performed using PubMed, Embase, and Web of Science (through June 2013). Studies were assessed for degree of relevance and strength of evidence, based on whether clinical implications of MISGD were the primary study outcomes, as well as on the appropriateness of study design and sample size. Results For most purported xerogenic medications, xerostomia was the most frequent adverse effect. In the majority of the 129 reviewed papers, it was not documented whether xerostomia was accompanied by decreased salivary flow. Incidence and prevalence of medication-induced xerostomia varied widely and was often associated with number and dose of medications. Xerostomia was most frequently reported to be mild-to-moderate in severity. Its onset occurred usually in the first weeks of treatment. There was selected evidence that medication-induced xerostomia occurs more frequently in women and older adults and that MISGD may be associated with other clinical implications, such as caries or oral mucosal alterations. Conclusions The systematic review showed that MISGD constitutes a significant burden in many patients and may be associated with important negative implications for oral health.

    Original languageAmerican English
    Pages (from-to)185-206
    Number of pages22
    JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
    Issue number2
    StatePublished - 2015

    Bibliographical note

    Publisher Copyright:
    © 2015 Elsevier Inc.


    Dive into the research topics of 'World Workshop on Oral Medicine VI: Clinical implications of medication-induced salivary gland dysfunction'. Together they form a unique fingerprint.

    Cite this