Wound-healing modulation in upper airway stenosis-myths and facts

Nir Hirshoren*, Ron Eliashar

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations

Abstract

Wound healing plays a major role in the development of acquired subglottic stenosis. Pharmacologic treatment of subglottic stenosis must address both physiologic and pathologic healing processes. The relevant Pubmed and Ovid databases from 1960 to 2007 were systematically searched. Several modulating agents have been tested. Most of them were poorly investigated. Three modalities were thoroughly studied - steroids and antibiotics, mitomycin, and antireflux medications. However, there are conflicting data regarding their role in preventing and treating subglottic stenosis. Current data support to some extent the textbook suggestions of antibiotics, steroids, and antireflux treatment. As no other treatment options exist, we recommend using these modalities for pharmacologic modulation of sub-glottic stenosis. Mitomycin should still be considered as an unproven treatment; its use may be considered as an adjunct.

Original languageAmerican English
Pages (from-to)111-126
Number of pages16
JournalHead and Neck
Volume31
Issue number1
DOIs
StatePublished - Jan 2009

Keywords

  • Airway stenosis
  • Larynx
  • Scar
  • Subglottic stenosis
  • Wound healing

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