WW domain-containing oxidoreductase's role in myriad cancers: Clinical significance and future implications

Aliza Gardenswartz, Rami I. Aqeilan

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

The WW domain-containing oxidoreductase (WWOX) gene, encodes a tumor suppressor located on 16q23.1, spanning FRA16D, one of the most active common fragile sites in the human genome, that is altered in numerous types of cancer. WWOX's alteration in these myriad cancers is due to disparate mechanisms including loss of heterozygosity, homozygous deletion and epigenetic changes. In vitro, WWOX has been found to be reduced or absent in numerous cancer cell lines and WWOX restoration has been found to inhibit tumor cell growth and invasion. Wwox knockout mice developed femoral focal lesions resembling osteosarcomas within one month of their life and aging Wwox heterozygous mice have an increased incidence of spontaneous lung and mammary tumors as well as B-cell lymphomas. We herein review WWOX's role that has been unearthed thus far in different types of malignancies, its clinical significance and future implications.

Original languageAmerican English
Pages (from-to)253-263
Number of pages11
JournalExperimental Biology and Medicine
Volume239
Issue number3
DOIs
StatePublished - Mar 2014

Bibliographical note

Funding Information:
The Aqeilan lab is funded, in part, by ICRF-Research Career Development Awards.

Keywords

  • WW domain-containing oxidoreductase
  • breast cancer
  • hypermethylation
  • lung cancer
  • tumor suppressor gene

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