WW domain-containing proteins: Retrospectives and the future

Zaidoun Salah, Akram Alian, Rami I. Aqeilan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations


WW domains are protein modules that mediate protein-protein interactions through recognition of prolinerich peptide motifs (PRM) and phosphorylated serine/threonine-proline sites. WW domains are found in many different structural and signaling proteins that are involved in a variety of cellular processes, including RNA transcription and processing, protein trafficking and stability, receptor signaling, and control of the cytoskeleton. WW domain-containing proteins and complexes have been implicated in major human diseases including cancer as well as in major signaling cascades such as the Hippo tumor suppressor pathway, making them targets for new diagnostics and therapeutics. In this review, we discuss how WW domains provide versatile platforms that link individual proteins into physiologically important networks and the indispensible role of WW domaincontaining proteins in biology and pathology, especially tumorogenesis.

Original languageAmerican English
Pages (from-to)331-348
Number of pages18
JournalFrontiers in Bioscience - Landmark
Issue number1
StatePublished - 1 Jan 2012


  • AIP4
  • Hippo Pathway
  • ITCH
  • Review
  • Tumor Suppressor
  • Tumorigenesis
  • WW domain
  • WWOX
  • YAP


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