WW domain interactions regulate the Hippo tumor suppressor pathway

Z. Salah, R. I. Aqeilan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations


The Hippo kinase pathway is emerging as a conserved signaling pathway that is essential for organ growth and tumorigenesis in Drosophila and mammalians. Although the signaling of the core kinases is relatively well understood, less is known about the upstream inputs, downstream outputs and regulation of the whole cascade. Enrichment of the Hippo pathway components with WW domains and their cognate proline-rich interacting motifs provides a versatile platform for further understanding the mechanisms that regulate organ growth and tumorigenesis. Here, we review recently discovered mechanisms of WW domain-mediated interactions that contribute to the regulation of the Hippo signaling pathway in tumorigenesis. We further discuss new insights and future directions on the emerging role of such regulation.

Original languageAmerican English
Article numbere172
JournalCell Death and Disease
Issue number6
StatePublished - Jun 2011

Bibliographical note

Funding Information:
Acknowledgements. We are grateful to Ms Sherri Cohen and Mrs Aliza Forman for critical reading of the manuscript. We apologize to those colleagues whose work we could not cite because of space limitation. This work was supported in part by the Israeli Science Foundation grant (ISF# 1331-08) and Marie Curie-European Re-integration Grant (Project# 224848) to Aqeilan RI and Israeli Cancer Research Fund (ICRF) to Salah Z.


  • Hippo pathway
  • ITCH
  • LATS1
  • Protein-protein interaction
  • WW domain


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