TY - JOUR
T1 - WWOX guards genome stability by activating ATM
AU - Hazan, Idit
AU - Abu-Odeh, Mohammad
AU - Hofmann, Thomas G.
AU - Aqeilan, Rami I.
N1 - Publisher Copyright:
© 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Idit Hazan, Mohammad Abu-Odeh, Thomas G Hofmann, and Rami I Aqeilan.
PY - 2015/10/2
Y1 - 2015/10/2
N2 - Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be “hot spots” for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates its activation to maintain genomic integrity.
AB - Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be “hot spots” for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates its activation to maintain genomic integrity.
UR - http://www.scopus.com/inward/record.url?scp=85019274911&partnerID=8YFLogxK
U2 - 10.1080/23723556.2015.1008288
DO - 10.1080/23723556.2015.1008288
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AN - SCOPUS:85019274911
SN - 2372-3556
VL - 2
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
IS - 4
M1 - e1008288
ER -