WWOX guards genome stability by activating ATM

Idit Hazan, Mohammad Abu-Odeh, Thomas G. Hofmann, Rami I. Aqeilan*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

8 Scopus citations

Abstract

Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be “hot spots” for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates its activation to maintain genomic integrity.

Original languageAmerican English
Article numbere1008288
JournalMolecular and Cellular Oncology
Volume2
Issue number4
DOIs
StatePublished - 2 Oct 2015

Bibliographical note

Publisher Copyright:
© 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Idit Hazan, Mohammad Abu-Odeh, Thomas G Hofmann, and Rami I Aqeilan.

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