TY - JOUR
T1 - WWOX in biological control and tumorigenesis
AU - Aqeilan, Rami I.
AU - Croce, Carlo M.
PY - 2007/8
Y1 - 2007/8
N2 - The WW domain-containing oxidoreductase (WWOX) gene is located at 16q23.1-16q23.2, a region that spans the second most common human fragile site, FRA16D. The WWOX protein contains two N-terminal WW domains and a central short chain oxidoreductase-like domain. In the last few years, considerable amount of data have shown inactivation of WWOX in a variety of human malignancies. Moreover, interacting partners have been identified biochemically that define, at least in part, the molecular mechanism of WWOX action. Recently, we demonstrated that targeted deletion of the Wwox gene in the mouse led to increased incidence of spontaneous and chemically induced tumor formation, thereby providing the first in vivo evidence that WWOX is a bona fide tumor suppressor. This review focuses on the most recent progress in understanding WWOX function as a tumor suppressor.
AB - The WW domain-containing oxidoreductase (WWOX) gene is located at 16q23.1-16q23.2, a region that spans the second most common human fragile site, FRA16D. The WWOX protein contains two N-terminal WW domains and a central short chain oxidoreductase-like domain. In the last few years, considerable amount of data have shown inactivation of WWOX in a variety of human malignancies. Moreover, interacting partners have been identified biochemically that define, at least in part, the molecular mechanism of WWOX action. Recently, we demonstrated that targeted deletion of the Wwox gene in the mouse led to increased incidence of spontaneous and chemically induced tumor formation, thereby providing the first in vivo evidence that WWOX is a bona fide tumor suppressor. This review focuses on the most recent progress in understanding WWOX function as a tumor suppressor.
UR - http://www.scopus.com/inward/record.url?scp=34347371806&partnerID=8YFLogxK
U2 - 10.1002/jcp.21099
DO - 10.1002/jcp.21099
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C2 - 17458891
AN - SCOPUS:34347371806
SN - 0021-9541
VL - 212
SP - 307
EP - 310
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
IS - 2
ER -