WWOX loss activates aerobic glycolysis

Muhannad Abu-Remaileh; Victoria L. Seewaldt; Rami I. Aqeilan

doi:10.4161/23723548.2014.965640

WWOX loss activates aerobic glycolysis

Muhannad Abu-Remaileh, Victoria L. Seewaldt, Rami I. Aqeilan^*

^*Corresponding author for this work

Department of Immunology and Cancer Research

Research output: Contribution to journal › Comment/debate

11 Scopus citations

Abstract

Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.

Original language	English
Article number	e965640
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	2
DOIs	https://doi.org/10.4161/23723548.2014.965640
State	Published - 3 Apr 2015

Bibliographical note

Publisher Copyright:
© 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Muhannad Abu-Remaileh, Victoria L Seewaldt, and Rami I Aqeilan.

Keywords

HIF1
WWOX
Warburg effect
aerobic glycolysis
breast cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/23723548.2014.965640

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title = "WWOX loss activates aerobic glycolysis",

abstract = "Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.",

keywords = "HIF1, WWOX, Warburg effect, aerobic glycolysis, breast cancer",

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N2 - Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.

AB - Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.

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WWOX loss activates aerobic glycolysis

Abstract

Bibliographical note

Keywords

UN SDGs

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