WWOX loss activates aerobic glycolysis

Muhannad Abu-Remaileh, Victoria L. Seewaldt, Rami I. Aqeilan*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

11 Scopus citations


Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.

Original languageAmerican English
Article numbere965640
JournalMolecular and Cellular Oncology
Issue number2
StatePublished - 3 Apr 2015

Bibliographical note

Publisher Copyright:
© 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Muhannad Abu-Remaileh, Victoria L Seewaldt, and Rami I Aqeilan.


  • HIF1
  • WWOX
  • Warburg effect
  • aerobic glycolysis
  • breast cancer


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