TY - JOUR
T1 - Y chromosome evidence for a founder effect in Ashkenazi Jews
AU - Nebel, Almut
AU - Filon, Dvora
AU - Faerman, Marina
AU - Soodyall, Himla
AU - Oppenheim, Ariella
PY - 2005/3
Y1 - 2005/3
N2 - Recent genetic studies, based on Y chromosome polymorphic markers, showed that Ashkenazi Jews are more closely related to other Jewish and Middle Eastern groups than to their host populations in Europe. However, Ashkenazim have an elevated frequency of R-M17, the dominant Y chromosome haplogroup in Eastern Europeans, suggesting possible gene flow. In the present study of 495 Y chromosomes of Ashkenazim, 57 (11.5%) were found to belong to R-M17. Detailed analyses of haplotype structure, diversity and geographic distribution suggest a founder effect for this haplogroup, introduced at an early stage into the evolving Ashkenazi community in Europe. R-M17 chromosomes in Ashkenazim may represent vestiges of the mysterious Khazars.
AB - Recent genetic studies, based on Y chromosome polymorphic markers, showed that Ashkenazi Jews are more closely related to other Jewish and Middle Eastern groups than to their host populations in Europe. However, Ashkenazim have an elevated frequency of R-M17, the dominant Y chromosome haplogroup in Eastern Europeans, suggesting possible gene flow. In the present study of 495 Y chromosomes of Ashkenazim, 57 (11.5%) were found to belong to R-M17. Detailed analyses of haplotype structure, diversity and geographic distribution suggest a founder effect for this haplogroup, introduced at an early stage into the evolving Ashkenazi community in Europe. R-M17 chromosomes in Ashkenazim may represent vestiges of the mysterious Khazars.
KW - Ashkenazi Jews
KW - Founder effect
KW - Y chromosome haplotypes
UR - http://www.scopus.com/inward/record.url?scp=14944376864&partnerID=8YFLogxK
U2 - 10.1038/sj.ejhg.5201319
DO - 10.1038/sj.ejhg.5201319
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 15523495
AN - SCOPUS:14944376864
SN - 1018-4813
VL - 13
SP - 388
EP - 391
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
IS - 3
ER -